An internal standard for the quantification of clenbuterol
Related Products
Unlabeled Version(s)
14985Clenbuterol (hydrochloride)
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Clenbuterol-d9

Item No. 40816

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-3,5-dichloro-α-[[[1,1-di(methyl-d3)ethyl-2,2,2-d3]amino]methyl]-benzenemethanol
CAS Number
129138-58-5
Synonyms
  • NAB 365-d9
Molecular Formula
C12H9Cl2D9N2O
Formula Weight
286.2
Purity
≥99% deuterated forms (d1-d9)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: Slightly soluble
SMILES
[2H]C([2H])([2H])C(C([2H])([2H])[2H])(C([2H])([2H])[2H])NCC(C1=CC(Cl)=C(C(Cl)=C1)N)O
InChi Code
InChI=1S/C12H18Cl2N2O/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7/h4-5,10,16-17H,6,15H2,1-3H3/i1D3,2D3,3D3
InChi Key
STJMRWALKKWQGH-GQALSZNTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Clenbuterol-d9 is intended for use as an internal standard for the quantification of clenbuterol (Item No. 14985) by GC- or LC-MS. Clenbuterol is an agonist of β2-adrenergic receptors (β2-ARs).1 It induces relaxation of equine tracheal muscle strips (EC50 = 2.1 nM). Clenbuterol (300 nM) increases the number of autophagosomes and autophagic flux in HepG2 cells.2 It increases blood flow to adipose tissue and induces weight gain in rats when administered at a dose of 2 mg/kg, as well as induces relaxation of bovine uterus.3,4 Clenbuterol also inhibits infection of MDCK cells by an H1N1 influenza isolate in vitro (EC50 = 9.4 µM).5 Formulations containing clenbuterol have been used in the treatment of airway obstruction in horses.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Törneke, K., Larsson, C.I., and Appelgren, L.E. A comparison between clenbuterol, salbutamol and terbutaline in relation to receptor binding and in vitro relaxation of equine tracheal muscle. J. Vet. Pharmacol. Ther. 21(5), 388-392 (1998).

    2. Farah, B.L., Sinha, R.A., Wu, Y., et al. β-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver. PLoS One 9(6), (2014).

    3. Rothwell, N.J., Stock, M.J., and Sudera, D.K. Changes in tissue blood flow and β-receptor density of skeletal muscle in rats treated with the β2-adrenoceptor agonist clenbuterol. Br. J. Pharmacol. 90(3), 601-607 (1987).

    4. Denooij, P.P. The use of clenbuterol for obstetrical procedures in forty cows and one horse. Can. Vet. J. 25(9), 357-359 (1984).

    5. Jang, Y., Shin, J.S., Lee, J.-Y., et al. In vitro and in vivo antiviral activity of nylidrin by targeting the hemagglutinin 2-mediated membrane fusion of influenza A virus. Viruses 12(5), 581 (2020).