A STING activator and anticancer agent
Related Products
Alternative(s)
40481PDIC-NS
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PDIC-NC

Item No. 40818

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6,12,13-tetrachloro-2,9-bis[2-(dimethylamino)ethyl]-anthra[2,1,9-def:6,5,10-d'e'f′]diisoquinoline-1,3,8,10(2H,9H)-tetrone, dihydrochloride
CAS Number
2633013-75-7
Molecular Formula
C32H24Cl4N4O4 • 2HCl
Formula Weight
743.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlMethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1N(CCN(C)C)C(C2=C(C1=CC(Cl)=C3C4=C(Cl)C=C(C(N(CCN(C)C)C5=O)=O)C6=C5C=C(Cl)C7=C46)C3=C7C(Cl)=C2)=O.Cl.Cl
InChi Code
InChI=1S/C32H24Cl4N4O4.2ClH/c1-37(2)5-7-39-29(41)13-9-17(33)23-25-19(35)11-15-22-16(32(44)40(31(15)43)8-6-38(3)4)12-20(36)26(28(22)25)24-18(34)10-14(30(39)42)21(13)27(23)24;;/h9-12H,5-8H2,1-4H3;2*1H
InChi Key
FFFBAHMNWCSWIN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $29

    Add

    5 mg

    $108

    Add

    10 mg

    $172

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent.1,2 It increases the levels of phosphorylated STING in Lewis lung carcinoma cells when used at a concentration of 2 µM.1 PDIC-NC decreases the viability of A549 and NCI H446 lung cancer cells (IC50s = 0.48 and 0.79 µg/ml, respectively).2 It increases the levels of reactive oxygen species (ROS) and decreases the oxygen consumption rate (OCR) in A549 and NCI H446 cells when used at concentrations of 1 and 2 µg/ml, respectively. PDIC-NC selectively accumulates in the lungs over the heart, liver, spleen, and kidneys in mice. Intravenous administration of PDIC-NC (2 mg/kg) reduces tumor volume and the number of metastases in A549 mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, X., Zheng, R., Zhang, B., et al. Sulfonated perylene as three-in-one STING agonist for cancer chemo-immunotherapy. Angew. Chem. Int. Ed. Engl. 63(11), e202318799 (2024).

    2. Liu, Z., Wang, X., Chen, Q., et al. Regulating twisted skeleton to construct organ-specific perylene for intensive cancer chemotherapy. Angew Chem. Int. Ed. Engl. 60(29), 16215-16223 (2021).