A STING activator and anticancer agent
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Alternative(s)
40481PDIC-NS
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PDIC-NC

Item No. 40818

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6,12,13-tetrachloro-2,9-bis[2-(dimethylamino)ethyl]-anthra[2,1,9-def:6,5,10-d'e'f′]diisoquinoline-1,3,8,10(2H,9H)-tetrone, dihydrochloride
CAS Number
2633013-75-7
Molecular Formula
C32H24Cl4N4O4 • 2HCl
Formula Weight
743.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlMethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1N(CCN(C)C)C(C2=C(C1=CC(Cl)=C3C4=C(Cl)C=C(C(N(CCN(C)C)C5=O)=O)C6=C5C=C(Cl)C7=C46)C3=C7C(Cl)=C2)=O.Cl.Cl
InChi Code
InChI=1S/C32H24Cl4N4O4.2ClH/c1-37(2)5-7-39-29(41)13-9-17(33)23-25-19(35)11-15-22-16(32(44)40(31(15)43)8-6-38(3)4)12-20(36)26(28(22)25)24-18(34)10-14(30(39)42)21(13)27(23)24;;/h9-12H,5-8H2,1-4H3;2*1H
InChi Key
FFFBAHMNWCSWIN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent.1,2 It increases the levels of phosphorylated STING in Lewis lung carcinoma cells when used at a concentration of 2 µM.1 PDIC-NC decreases the viability of A549 and NCI H446 lung cancer cells (IC50s = 0.48 and 0.79 µg/ml, respectively).2 It increases the levels of reactive oxygen species (ROS) and decreases the oxygen consumption rate (OCR) in A549 and NCI H446 cells when used at concentrations of 1 and 2 µg/ml, respectively. PDIC-NC selectively accumulates in the lungs over the heart, liver, spleen, and kidneys in mice. Intravenous administration of PDIC-NC (2 mg/kg) reduces tumor volume and the number of metastases in A549 mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, X., Zheng, R., Zhang, B., et al. Sulfonated perylene as three-in-one STING agonist for cancer chemo-immunotherapy. Angew. Chem. Int. Ed. Engl. 63(11), e202318799 (2024).

    2. Liu, Z., Wang, X., Chen, Q., et al. Regulating twisted skeleton to construct organ-specific perylene for intensive cancer chemotherapy. Angew Chem. Int. Ed. Engl. 60(29), 16215-16223 (2021).