Cab45 (37-362) (human, recombinant)

45 kDa Calcium-binding protein (Cab45), also known as stromal cell-derived factor 4 (SDF-4), is a member of the Cab45/reticulocalbin/ERC45/calumenin (CREC) protein family encoded by SDF4 in humans.^1,2 SDF4 encodes a 362-amino acid precursor protein that contains an N-terminal signal sequence, six EF-hand motifs, and a C-terminal HEEF motif. Alternative splicing produces three isoforms: the Golgi-localized variant Cab45-G, the cytosolic variant Cab45-C, and the secreted variant Cab45-S, each with different domain composition, as well as physiological and pathophysiological roles.^1,2,3 Cab45 levels are increased in PANC-1 pancreatic, LIM1215 colorectal, and HeLa cervical cancer cells.³ SDF4^-/- induces perinuclear accumulation of lysosomes and secretion of the unprocessed protein precursors prosaposin and progranulin in HeLa cells, indicating a role for Cab45 in lysosomal positioning.⁴

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1. Chi, J.Y., Hsiao, Y.W., Liu, H.L., et al. Fibroblast CEBPD/SDF4 axis in response to chemotherapy-induced angiogenesis through CXCR4. Cell Death Discov. 7(1), 94 (2021).

2. Honoré, B. The rapidly expanding CREC protein family: Members, localization, function, and role in disease. Bioessays 31(3), 262-277 (2009).

3. Gong, W., Martin, T.A., Sanders, A.J., et al. Location, function and role of stromal cell‑derived factors and possible implications in cancer (review). Int. J. Mol. Med. 47(2), 435-443 (2021).

4. Tran, M.L., Tüshaus, J., Kim, Y., et al. Cab45 deficiency leads to the mistargeting of progranulin and prosaposin and aberrant lysosomal positioning. Traffic 24(1), 4-19 (2023).