A pre-prodrug form of sodium 4-phenylbutyrate
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Glycerol Phenylbutyrate

Item No. 40832

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
benzenebutanoic acid, 1,1′,1′′-(1,2,3-propanetriyl) ester
CAS Number
611168-24-2
Synonyms
  • GPB
  • HPN-100
Molecular Formula
C33H38O6
Formula Weight
530.7
Purity
≥95%
Formulation
A neat oil
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
O=C(CCCC1=CC=CC=C1)OC(COC(CCCC2=CC=CC=C2)=O)COC(CCCC3=CC=CC=C3)=O
InChi Code
InChI=1S/C33H38O6/c34-31(22-10-19-27-13-4-1-5-14-27)37-25-30(39-33(36)24-12-21-29-17-8-3-9-18-29)26-38-32(35)23-11-20-28-15-6-2-7-16-28/h1-9,13-18,30H,10-12,19-26H2
InChi Key
ZSDBFLMJVAGKOU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    50 mg

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    100 mg

    $165

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    Product Description

    Glycerol phenylbutyrate is a pre-prodrug form of the nitrogen-binding prodrug and chemical chaperone sodium 4-phenylbutyrate (Item No. 11323).1 It is converted by pancreatic lipase in the small intestine to sodium 4-phenylbutyrate, which is subsequently converted into the active metabolite phenylacetate via β-oxidation. Formulations containing glycerol phenylbutyrate have been used in the treatment of urea cycle disorders that cannot be managed by diet or amino acid supplementation alone.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oishi, K., and Diaz, G.A. Glycerol phenylbutyrate for the chronic management of urea cycle disorders. Expert Rev. Endocrinol. Metab. 9(5), 427-434 (2014).