An inhibitor of influenza neuraminidases and a prodrug form of laninamivir
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Laninamivir octanoate

Item No. 40850

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid, 9-octanoate
CAS Number
203120-46-1
Synonyms
  • CS 8958
Molecular Formula
C21H36N4O8
Formula Weight
472.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
OC(C1=C[C@H](NC(N)=N)[C@@H](NC(C)=O)[C@@]([C@@H]([C@@H](COC(CCCCCCC)=O)O)OC)([H])O1)=O
InChi Code
InChI=1S/C21H36N4O8/c1-4-5-6-7-8-9-16(28)32-11-14(27)18(31-3)19-17(24-12(2)26)13(25-21(22)23)10-15(33-19)20(29)30/h10,13-14,17-19,27H,4-9,11H2,1-3H3,(H,24,26)(H,29,30)(H4,22,23,25)/t13-,14+,17+,18+,19+/m0/s1
InChi Key
UKTIJASCFRNWCB-RMIBSVFLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Laninamivir octanoate is an inhibitor of influenza neuraminidases and a prodrug form of laninamivir.1 It selectively inhibits the neuraminidases from influenza A H1N1, H2N2, and H3N2 strains (mean IC50s = 822, 128, and 114 nM, respectively) over the neuraminidases from influenza B Victoria and Yamagata strains (mean IC50s = >10,000 nM for both). Intranasal administration of laninamivir octanoate (0.95 µg/kg) increases survival in a mouse model of lethal influenza H1N1 infection. Formulations containing laninamivir octanoate have been used in the prevention of influenza.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamashita, M., Tomozawa, T., Kakuta, M., et al. CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity. Antimicrob. Agents Chemother. 53(1), 186-192 (2009).