An ApoL1 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Inaxaplin

Item No. 40852

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-difluoro-2-(4-fluorophenyl)-N-[(3S,4R)-4-hydroxy-2-oxo-3-pyrrolidinyl]-1H-indole-3-propanamide
CAS Number
2446816-88-0
Synonyms
  • VX-147
Molecular Formula
C21H18F3N3O3
Formula Weight
417.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/ml
SMILES
FC1=CC(F)=C2NC(C3=CC=C(F)C=C3)=C(CCC(N[C@H]4[C@H](O)CNC4=O)=O)C2=C1
InChi Code
InChI=1S/C21H18F3N3O3/c22-11-3-1-10(2-4-11)18-13(14-7-12(23)8-15(24)19(14)27-18)5-6-17(29)26-20-16(28)9-25-21(20)30/h1-4,7-8,16,20,27-28H,5-6,9H2,(H,25,30)(H,26,29)/t16-,20+/m1/s1
InChi Key
CTXLPYZCBOVVQK-UZLBHIALSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $108

    Add

    5 mg

    $513

    Add

    10 mg

    $917

    Add

    25 mg

    $1,348

    Add
    Product Description

    Inaxaplin is an apolipoprotein L1 (ApoL1) inhibitor.1 It inhibits cytotoxicity induced by overexpression of the APOL1 variants G1 and G2 in cells when used at a concentration of 3 µM. Inaxaplin also reduces ApoL1 G1-induced inhibition of global protein synthesis in podocytes isolated from APOL1 transgenic mice. In vivo, inaxaplin (10 mg/kg) reduces podocyte injury and proteinuria in APOL1 transgenic mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Datta, S., Antonio, B.M., Zahler, N.H., et al. APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease. J. Clin. Invest. 134(5), (2024).