An ApoL1 inhibitor
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Inaxaplin

Item No. 40852

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-difluoro-2-(4-fluorophenyl)-N-[(3S,4R)-4-hydroxy-2-oxo-3-pyrrolidinyl]-1H-indole-3-propanamide
CAS Number
2446816-88-0
Synonyms
  • VX-147
Molecular Formula
C21H18F3N3O3
Formula Weight
417.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/ml
SMILES
FC1=CC(F)=C2NC(C3=CC=C(F)C=C3)=C(CCC(N[C@H]4[C@H](O)CNC4=O)=O)C2=C1
InChi Code
InChI=1S/C21H18F3N3O3/c22-11-3-1-10(2-4-11)18-13(14-7-12(23)8-15(24)19(14)27-18)5-6-17(29)26-20-16(28)9-25-21(20)30/h1-4,7-8,16,20,27-28H,5-6,9H2,(H,25,30)(H,26,29)/t16-,20+/m1/s1
InChi Key
CTXLPYZCBOVVQK-UZLBHIALSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $108

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    5 mg

    $513

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    10 mg

    $917

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    25 mg

    $1,348

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    Product Description

    Inaxaplin is an apolipoprotein L1 (ApoL1) inhibitor.1 It inhibits cytotoxicity induced by overexpression of the APOL1 variants G1 and G2 in cells when used at a concentration of 3 µM. Inaxaplin also reduces ApoL1 G1-induced inhibition of global protein synthesis in podocytes isolated from APOL1 transgenic mice. In vivo, inaxaplin (10 mg/kg) reduces podocyte injury and proteinuria in APOL1 transgenic mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Datta, S., Antonio, B.M., Zahler, N.H., et al. APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease. J. Clin. Invest. 134(5), (2024).