A cyclic peptide with anticancer activity
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Mechercharmycin A

Item No. 40868

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclo[D-alloisoleucyl-L-valyl-2′-[2-[2′-(1-aminoethenyl)[2,4′-bioxazol]-4-yl]-4-thiazolyl]-5-phenyl[2,4′-bioxazole]-4-carbonyl]
CAS Number
822520-96-7
Synonyms
  • IB-01211
Molecular Formula
C35H32N8O7S
Formula Weight
708.7
Purity
≥70%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
O=C(N[C@](C(N[C@H](C(NC(C1=NC2=CO1)=C)=O)C(C)C)=O)([H])[C@@H](C)CC)C3=C(C4=CC=CC=C4)OC(C5=COC(C6=CSC(C7=COC2=N7)=N6)=N5)=N3
InChi Code
InChI=1S/C35H32N8O7S/c1-6-17(4)25-29(45)41-24(16(2)3)28(44)36-18(5)31-37-20(12-47-31)32-39-22(14-49-32)35-40-23(15-51-35)33-38-21(13-48-33)34-43-26(30(46)42-25)27(50-34)19-10-8-7-9-11-19/h7-17,24-25H,5-6H2,1-4H3,(H,36,44)(H,41,45)(H,42,46)/t17-,24-,25+/m0/s1
InChi Key
YIJVJFCLUNYXQX-WGXRPPGPSA-N
Origin
Bacterium/Mechercharimyces mesophilus
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $644

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    Product Description

    Mechercharmycin A is a cyclic peptide originally isolated from Thermoactinomyces that has anticancer activity.1 It induces cytotoxicity in A549 lung cancer and Jurkat leukemia cells (IC50s = 40 and 46 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kanoh, K., Matsuo, Y., Adachi, K., et al. Mechercharmycins A and B, cytotoxic substances from marine-derived Thermoactinomyces sp. YM3-251. J. Antibiot. (Tokyo) 58(4), 289-292 (2005).