Host: Insect cells • AA: 367-606 • Tag: C-terminal His • MW: 27.7 kDa
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MERS-CoV Spike Glycoprotein RBD (Strain EMC/2012) (recombinant)

Item No. 40876

Product Insert (PDF)
Technical Information
Synonyms
  • MERS-CoV Spike Glycoprotein Receptor-Binding Domain
  • Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein RBD
  • Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein Receptor-Binding Domain
Purity
≥90% as estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/µg determined by the LAL endotoxin assay
Source
Recombinant MERS-CoV C-terminal His-tagged spike glycoprotein RBD expressed in insect cells
Amino Acids
367-606
MW
27.7 kDa
Formulation (Request formulation change)
Lyophilized from sterile 20 mM Tris, 500 mM sodium chloride, 10% glycerol, pH 8.0
UniProt Accession №
K0BRG7
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $493

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    Cayman Chemical
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    Product Description

    Middle East respiratory syndrome coronavirus (MERS-CoV) spike glycoprotein is a viral structural protein that contains the receptor-binding domain (RBD).1 MERS-CoV is an enveloped positive-stranded RNA virus, a member of the Betacoronavirus genus, and the causative agent of MERS, an acute respiratory disease that often leads to pneumonia and renal failure.1,2 The MERS-CoV spike glycoprotein mediates viral attachment to host cells and virus-cell-mediated membrane fusion during infection.1 It is composed of an S1 subunit, which contains the RBD that binds to host dipeptidyl peptidase-4 (DPP-4), and an S2 subunit containing heptad repeat regions 1 and 2, which are responsible for membrane fusion, as well as a transmembrane domain and a cytoplasmic tail. The RBD of the MERS-CoV spike glycoprotein is one of the targets for neutralizing antibodies.1 Cayman's MERS-CoV Spike Glycoprotein RBD (Strain EMC/2012) (recombinant) protein consists of 251 amino acids and has a calculated molecular weight of 27.7 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Du, L., Yang, Y., Zhou, Y., et al. MERS-CoV spike protein: A key target for antivirals. Expert Opin. Ther. Targets 21(2), 131-143 (2017).

    2. Rabaan, A.A., Al-Ahmed, S.H., Haque, S., et al. SARS-CoV-2, SARS-CoV, and MERS-CoV: A comparative overview. Infez. Med. 28(2), 174-184 (2020).