An ionizable cationic lipid
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Lipid U-101

Item No. 40902

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
bis(2-hexyldecyl) 6,6'-((3-(bis(2-hydroxyethyl)amino)propyl)azanediyl)dihexanoate
CAS Number
3049129-09-8
Molecular Formula
C51H102N2O6
Formula Weight
839.4
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
OCCN(CCO)CCCN(CCCCCC(OCC(CCCCCC)CCCCCCCC)=O)CCCCCC(OCC(CCCCCC)CCCCCCCC)=O
InChi Code
InChI=1S/C51H102N2O6/c1-5-9-13-17-19-25-34-48(32-23-15-11-7-3)46-58-50(56)36-27-21-29-38-52(40-31-41-53(42-44-54)43-45-55)39-30-22-28-37-51(57)59-47-49(33-24-16-12-8-4)35-26-20-18-14-10-6-2/h48-49,54-55H,5-47H2,1-4H3
InChi Key
MKIYWSRHXLMSER-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $169

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    10 mg

    $286

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    25 mg

    $674

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    50 mg

    $1,095

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    Cayman Chemical
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    Product Description

    Lipid U-101 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing lipid U-101 and encapsulating mRNA encoding a fusion protein composed of IL-2, a linker, and CD25 inhibit tumor growth in an MC-38 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jiang, Y., Zhang, Y., Liu, C., et al. Tumor-activated IL-2 mRNA delivered by lipid nanoparticles for cancer immunotherapy. J. Control. Release 368, 663-675 (2024).