A derivative of PMA
Related Products
Isomer(s)
24479Phorbol
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4α-Phorbol

Item No. 40905

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1aR,1bS,4,4aS,7aS,7bS,8R,9R,9aS-decahydro-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one
CAS Number
26241-63-4
Synonyms
  • Isophorbol
  • PDD
Molecular Formula
C20H28O6
Formula Weight
364.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlMethanol: Sparingly soluble: 1-10 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
OCC1=C[C@]2([H])[C@]([C@@](C=C(C)C3=O)([H])[C@@]3(O)C1)(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]2C4(C)C
InChi Code
InChI=1S/C20H28O6/c1-9-5-13-18(24,15(9)22)7-11(8-21)6-12-14-17(3,4)20(14,26)16(23)10(2)19(12,13)25/h5-6,10,12-14,16,21,23-26H,7-8H2,1-4H3/t10-,12+,13-,14-,16-,18+,19-,20-/m1/s1
InChi Key
QGVLYPPODPLXMB-FYYCTCHMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $495

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    Product Description

    4α-Phorbol is a derivative of the PKC activator phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).1 It induces chromosomal damage in mouse bone marrow erythroblasts ex vivo after administration of a 616 ng/ml dose, an effect that can be inhibited by prostaglandin E1 (PGE1; Item No. 13010).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Das, U.N., and Rao, K.P. Effect of γ-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice. Prostaglandins Leukot. Essent. Fatty Acids 74(3), 165-173 (2006).