An ionizable cationic lipid
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Lipid N2-3L

Item No. 40911

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9Z-octadecenoic acid, 3-[2-[(2-hexyl-1-oxodecyl)oxy]ethyl]-14-hydroxy-12-(2-hydroxyethyl)-7-oxo-6-oxa-3,8,12-triazatetradec-1-yl ester
CAS Number
2924606-55-1
Molecular Formula
C48H93N3O8
Formula Weight
840.3
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
O=C(CCCCCCC/C=C\CCCCCCCC)OCCN(CCOC(NCCCN(CCO)CCO)=O)CCOC(C(CCCCCCCC)CCCCCC)=O
InChi Code
InChI=1S/C48H93N3O8/c1-4-7-10-13-15-16-17-18-19-20-21-22-23-25-28-32-46(54)57-42-37-51(39-44-59-48(56)49-33-29-34-50(35-40-52)36-41-53)38-43-58-47(55)45(30-26-12-9-6-3)31-27-24-14-11-8-5-2/h18-19,45,52-53H,4-17,20-44H2,1-3H3,(H,49,56)/b19-18-
InChi Key
NKBLIRCFPYOMID-HNENSFHCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) that has been used in the generation of supramolecular lipid nanoparticles (SMLNPs) encapsulating mRNA for use in vitro and in vivo.1 SMLNPs containing lipid N2-3L and encapsulating a luciferase reporter accumulate at the site of injection and in the draining lymph nodes of mice. Lipid N2-3L-containing SMLNPs encapsulating ovalbumin mRNA and the toll-like receptor 7/8 (TLR7/8) agonist R-848 (Item No. 14806) as an adjuvant promote dendritic cell maturation and antigen presentation, reduce tumor volume, and increase survival in an MC-38-OVA murine model of colon cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qi, S., Zhang, X., Yu, X., et al. Supramolecular lipid nanoparticles based on host-guest recognition: A new generation delivery system of mrna vaccines for cancer immunotherapy. Adv. Mater. 36(23), e2311574 (2024).