An unsaturated ionizable cationic lipid
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Lipid 29d

Item No. 40913

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-(dimethylamino)propyl]-4,5,6,7-tetrahydro-6-[(9Z,12Z)-1-oxo-9,12-octadecadien-1-yl]-2-[[(9Z,12Z)-1-oxo-9,12-octadecadien-1-yl]amino]-thieno[2,3-c]pyridine-3-carboxamide
CAS Number
2921586-67-4
Molecular Formula
C49H82N4O3S
Formula Weight
807.3
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly Soluble: 1-10 mg/ml
SMILES
CCCCC/C=C\C/C=C\CCCCCCCC(N1CCC(C(C(NCCCN(C)C)=O)=C(NC(CCCCCCC/C=C\C/C=C\CCCCC)=O)S2)=C2C1)=O
InChi Code
InChI=1S/C49H82N4O3S/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-45(54)51-49-47(48(56)50-39-35-40-52(3)4)43-38-41-53(42-44(43)57-49)46(55)37-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22H,5-12,17-18,23-42H2,1-4H3,(H,50,56)(H,51,54)/b15-13-,16-14-,21-19-,22-20-
InChi Key
PSUMBQCAYICKHV-KWXKLSQISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Lipid 29d is an unsaturated ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 Intravenous administration of LNPs containing lipid 29d and encapsulating mRNA encoding a luciferase reporter induce bioluminescence in the lungs and spleen of mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eygeris, Y., Gupta, M., Kim, J., et al. Thiophene-based lipids for mRNA delivery to pulmonary and retinal tissues. Proc. Natl. Acad. Sci. USA 121(11), e2307813120 (2024).