A TLR7 agonist
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SMU-L11

Item No. 40914

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-butyl-1-[(tetrahydro-3-furanyl)methyl]-1H-imidazo[4,5-c]quinolin-4-amine
CAS Number
3029695-07-3
Molecular Formula
C19H24N4O
Formula Weight
324.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/mlChloroform: Sparingly Soluble: 1-10 mg/ml
SMILES
NC1=NC2=C(C=CC=C2)C3=C1N=C(CCCC)N3CC4COCC4
InChi Code
InChI=1S/C19H24N4O/c1-2-3-8-16-22-17-18(23(16)11-13-9-10-24-12-13)14-6-4-5-7-15(14)21-19(17)20/h4-7,13H,2-3,8-12H2,1H3,(H2,20,21)
InChi Key
YRCAPNRYNCJHGV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $89

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    10 mg

    $579

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    Product Description

    SMU-L11 is a toll-like receptor 7 (TLR7) agonist.1 It selectively activates TLR7 over TLR8 signaling in a cell-based reporter assay (EC50s = 0.024 and 4.9 µM, respectively) and is inactive at TLR2, -3, and -4 up to 100 µM. SMU-L11 enhances the protein-protein interaction between TLR7 and MyD88 and increases the phosphorylation of p65, p38, JNK, ERK1/2, and IFN regulatory factor 7 (IRF7) in isolated mouse bone marrow-derived dendritic cells (BMDCs). SMU-L11 increases TNF-α and IL-6 levels in RAW 264.7 macrophages and isolated mouse BMDCs and TNF-α and IL-1β levels in isolated human peripheral blood mononuclear cells (PBMCs). SMU-L11 increases the number of splenic and tumoral natural killer (NK) cells, CD4+ and CD8+ T cells, and M1-like macrophages and reduces tumor growth in a B16/F10 murine melanoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ou, J., Zheng, L., Chen, Y., et al. Heterocyclic-modified imidazoquinoline derivatives: Selective TLR7 agonist regulates tumor microenvironment against melanoma. J. Med. Chem. 67(5), 3321-3338 (2024).