An M1 muscarinic receptor PAM
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ML-137

Item No. 40918

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-1H-indole-2,3-dione
CAS Number
1222834-53-8
Synonyms
  • VU0366369
Molecular Formula
C19H14FN3O2
Formula Weight
335.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly Soluble: 0.1-1 mg/ml
SMILES
FC1=CC(C2=CN(C)N=C2)=CC=C1CN3C(C(C4=C3C=CC=C4)=O)=O
InChi Code
InChI=1S/C19H14FN3O2/c1-22-10-14(9-21-22)12-6-7-13(16(20)8-12)11-23-17-5-3-2-4-15(17)18(24)19(23)25/h2-10H,11H2,1H3
InChi Key
JCOKRGWZMBZKFO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $138

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    10 mg

    $262

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    50 mg

    $620

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    100 mg

    $1,032

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    Product Description

    ML-137 is a positive allosteric modulator (PAM) of M1 muscarinic acetylcholine receptors (mAChRs).1 It is selective for M1 over M2-M5 mAChRs at 30 µM. ML-137 potentiates ACh-induced activation of the M1 muscarinic receptor (EC50 = 0.83 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bridges, T.M., Phillip Kennedy, J., Noetzel, M.J., et al. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: Development of a potent and highly selective M1 PAM. Bioorg. Med. Chem. Lett. 20(6), 1972-1975 (2010).