A bile acid amidate
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N-Cholyl-L-Leucine

Item No. 40930

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-L-leucine
CAS Number
22154-46-7
Synonyms
  • N-Cholyl-Leu
  • Leucocholic Acid
Molecular Formula
C30H51NO6
Formula Weight
521.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
C[C@H](CCC(N[C@@H](CC(C)C)C(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C
InChi Code
InChI=1S/C30H51NO6/c1-16(2)12-23(28(36)37)31-26(35)9-6-17(3)20-7-8-21-27-22(15-25(34)30(20,21)5)29(4)11-10-19(32)13-18(29)14-24(27)33/h16-25,27,32-34H,6-15H2,1-5H3,(H,31,35)(H,36,37)/t17-,18+,19-,20-,21+,22+,23+,24-,25+,27+,29+,30-/m1/s1
InChi Key
LZFOJLAZIRIBIG-PJGKWPCRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $125

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    50 mg

    $238

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    100 mg

    $450

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    Product Description

    N-Cholyl-L-leucine is a bile acid amidate.1 It has been found in fecal samples from extremely premature infants with mild or severe brain injuries. N-Cholyl-L-leucine has been used as a standard for the detection of endogenous bile acid amidates in human plasma and fecal samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pristner, M., Wasinger, D., Seki, D., et al. Neuroactive metabolites and bile acids are altered in extremely premature infants with brain injury. Cell Rep. Med. 5(4), 101480 (2024).