A macrolide with antibacterial and anticancer activities
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IB-96212

Item No. 40938

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4E,18E,20E)-3′,4′,5′,6′-tetrahydro-7,9,11,12,13,14,15-heptahydroxy-6′-(2-hydroxy-1-methylbutyl)-22-(2-hydroxypropyl)-5′,6,8,16,28,29-hexamethyl-14-propyl-10-[(tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)oxy]-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2′-[2H]pyran]-3-one
CAS Number
220858-11-7
Molecular Formula
C54H94O16
Formula Weight
999.3
Purity
≥70%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Dichloromethane: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
CC1C(O)CCC(OC(C(O)C(C(O)C(CCC)(O)C(O)C(C)C/C=C\C=C\C(CC(C)O)CCC(OC2(OC(C(C)C(O)CC)C(C)CC2)C3C)([H])C(C)C3([H])O4)O)C(C(C(O)C(C)/C=C/C4=O)C)O)O1
InChi Code
InChI=1S/C54H94O16/c1-12-26-53(65)51(63)31(5)17-15-14-16-18-38(28-32(6)55)20-22-41-34(8)49(36(10)54(69-41)27-25-30(4)48(70-54)33(7)39(56)13-2)67-42(58)23-19-29(3)44(59)35(9)45(60)50(46(61)47(62)52(53)64)68-43-24-21-40(57)37(11)66-43/h14-16,18-19,23,29-41,43-52,55-57,59-65H,12-13,17,20-22,24-28H2,1-11H3/b15-14-,18-16+,23-19+
InChi Key
ZJMNECRCNSUGSV-BFNXMDKUSA-N
Origin
Bacterium/Micromonospora sediminimaris
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $43

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    5 mg

    $172

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    10 mg

    $280

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    25 mg

    $429

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    Cayman Chemical
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    Product Description

    IB-96212 is a macrolide that has been found in Micromonospora and has antibacterial and anticancer activities.1 It is active against M. luteus, B. subtilis, and S. aureus (MICs = 0.4, 100, and 100 µg/ml, respectively). IB-96212 induces death in P388 leukemia, A549 lung cancer, HT-29 colon cancer, and SK-MEL-28 melanoma cells (IC50s = 0.0001, 1, 1, and 1 µg/ml, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fernández-Chimeno, R.I., Cañedo, L., Espliego, F., et al. IB-96212, a novel cytotoxic macrolide produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot. (Tokyo) 53(5), 474-478 (2000).