A general anesthetic
Related Products
Metabolite(s)
42168Cipepofol Glucuronide
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Cipepofol

Item No. 40951

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(1R)-1-cyclopropylethyl]-6-(1-methylethyl)-phenol
CAS Number
1637741-58-2
Synonyms
  • Ciprofol
  • HSK3486
Molecular Formula
C14H20O
Formula Weight
204.3
Purity
≥98%
Formulation
A neat liquid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
CC(C1=CC=CC([C@H](C)C2CC2)=C1O)C
InChi Code
InChI=1S/C14H20O/c1-9(2)12-5-4-6-13(14(12)15)10(3)11-7-8-11/h4-6,9-11,15H,7-8H2,1-3H3/t10-/m1/s1
InChi Key
BMEARIQHWSVDBS-SNVBAGLBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $65

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    5 mg

    $244

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    10 mg

    $390

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    50 mg

    $974

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    Product Description

    Cipepofol is a general anesthetic.1 It binds to the GABAA receptor when used at a concentration of 10 µM. Cipepofol inhibits decreases in superoxide dismutase (Sod) levels, increases in NADPH oxidase (Nox) levels, and apoptosis induced by the β1- and β2-adrenergic receptor agonist isoproterenol (Item No. 15592) in H9c2 rat cardiomyocytes and reduces infarct size in a mouse model of isoproterenol-induced myocardial infarction.2 It induces loss of righting reflex (LORR) in mice (ED50 = 1.5 mg/kg).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qin, L., Ren, L., Wan, S., et al. Design, synthesis, and evaluation of novel 2,6-disubstituted phenol derivatives as general anesthetics. J. Med. Chem. 60(9), 3606-3617 (2017).

    2. Yang, Y., Xia, Z., Xu, C., et al. Ciprofol attenuates the isoproterenol-induced oxidative damage, inflammatory response and cardiomyocyte apoptosis. Front. Pharmacol. 13, 1037151 (2022).