A vanin-1 inhibitor
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PFI-653

Item No. 40955

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-oxa-2-azaspiro[4.5]dec-2-yl[2-[(2-pyrazinylmethyl)amino]-5-pyrimidinyl]-methanone
CAS Number
2173134-00-2
Synonyms
  • Vanin 1-IN-1
  • Vanin 1 Inhibitor 1
  • VNN1-IN-1
  • VNN1 Inhibitor 1
Molecular Formula
C18H22N6O2
Formula Weight
354.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(N1CC2(CCOCC2)CC1)C3=CN=C(N=C3)NCC4=NC=CN=C4
InChi Code
InChI=1S/C18H22N6O2/c25-16(24-6-1-18(13-24)2-7-26-8-3-18)14-9-21-17(22-10-14)23-12-15-11-19-4-5-20-15/h4-5,9-11H,1-3,6-8,12-13H2,(H,21,22,23)
InChi Key
VGRLXWFIXGZRMS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $59

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    50 mg

    $263

    Add

    100 mg

    $438

    Add

    250 mg

    $1,021

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    Product Description

    PFI-653 is an inhibitor of the pantetheinase vanin-1 (IC50 = 6.85 nM for the human enzyme).1 In vivo, PFI-653 (50 mg/kg) prevents reductions in body weight, as well as reduces disease severity and serum vanin-1 levels in a mouse model of colitis induced by dextran sulfate sodium (DSS; Item No. 23250). See the Structural Genomics Consortium (SGC) website for more information.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Casimiro-Garcia, A., Allais, C., Brennan, A., et al. Discovery of a series of pyrimidine carboxamides as inhibitors of vanin-1. J. Med. Chem. 65(1), 757-784 (2022).