A K2P13.1/THIK1 channel inhibitor
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CVN293

Item No. 40983

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[7-fluoro-1-(3-pyridazinylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine
CAS Number
2815296-08-1
Molecular Formula
C14H10FN7O
Formula Weight
311.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
NC1=NON=C1C2=NC3=CC=CC(F)=C3N2CC4=CC=CN=N4
InChi Code
InChI=1S/C14H10FN7O/c15-9-4-1-5-10-12(9)22(7-8-3-2-6-17-19-8)14(18-10)11-13(16)21-23-20-11/h1-6H,7H2,(H2,16,21)
InChi Key
ONRXHVJHFORDDI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $75

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    5 mg

    $318

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    10 mg

    $546

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    Product Description

    CVN293 is an inhibitor of the two-pore domain potassium channel K2P13.1/THIK1 (IC50 = 49 nM).1 It is selective for K2P13.1/THIK1 over K2P6.1/TWIK2 and K2P2.1/TREK-1 channels (IC50s = >30,000 nM for both). CVN293 inhibits NOD-like receptor protein 3 (NLRP3) inflammasome-mediated IL-1ß production in LPS-stimulated primary neonatal murine microglia (IC50 = 24 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bürli, R.W., Doyle, K.J., Dickson, L., et al. Discovery of CVN293, a brain permeable KCNK13 (THIK-1) inhibitor suitable for clinical assessment. ACS Med. Chem. Lett. 15(5), 646-652 (2024).