A CAII inhibitor
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NSC 44625

Item No. 40985

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-6-(trifluoromethyl)-1,3-benzenedisulfonamide
CAS Number
654-62-6
Synonyms
  • Bendroflumethiazide Impurity A
  • 2,4-Disulfamyl-5-trifluoromethylaniline
Molecular Formula
C7H8F3N3O4S2
Formula Weight
319.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/ml
SMILES
O=S(N)(C1=C(N)C=C(C(F)(F)F)C(S(=O)(N)=O)=C1)=O
InChi Code
InChI=1S/C7H8F3N3O4S2/c8-7(9,10)3-1-4(11)6(19(13,16)17)2-5(3)18(12,14)15/h1-2H,11H2,(H2,12,14,15)(H2,13,16,17)
InChi Key
KRVABEGPNKGLOT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $109

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    500 mg

    $207

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    Product Description

    NSC 44625 is an inhibitor of carbonic anhydrase II (CAII; Ki = 63 nM for the human enzyme).1 It is selective for CAII over CAI (Ki = 5,800 nM for the human enzyme) but also inhibits β-carbonic anhydrase (Ki = 223 nM for the S. cerevisiae enzyme).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Isik, S., Kockar, F., Aydin, M., et al. Carbonic anhydrase inhibitors: inhibition of the β-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates. Bioorg. Med. Chem. 17(3), 1158-1163 (2009).