A URAT1 antagonist
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Dotinurad

Item No. 41014

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3,5-dichloro-4-hydroxyphenyl)(1,1-dioxido-3(2H)-benzothiazolyl)-methanone
CAS Number
1285572-51-1
Synonyms
  • FYU-981
Molecular Formula
C14H9Cl2NO4S
Formula Weight
358.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(N1C2=C(S(=O)(C1)=O)C=CC=C2)C3=CC(Cl)=C(C(Cl)=C3)O
InChi Code
InChI=1S/C14H9Cl2NO4S/c15-9-5-8(6-10(16)13(9)18)14(19)17-7-22(20,21)12-4-2-1-3-11(12)17/h1-6,18H,7H2
InChi Key
VOFLAIHEELWYGO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $358

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    Product Description

    Dotinurad is a urate transporter 1 (URAT1) antagonist (IC50 = 0.0372 µM).1 It is selective for URAT1 over ATP-binding cassette subfamily G member 2 (ABCG2), organic anion transporter 1 (OAT1), and OAT3 (IC50s = 4.16, 4.08, and 1.32 µM, respectively). In vivo, dotinurad (30 mg/kg) decreases plasma levels of urate and increases urine levels of urate in Cebus monkeys. Formulations containing dotinurad have been used in the treatment of hyperuricemia and gout.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Taniguchi, T., Ashizawa, N., Matsumoto, K., et al. Pharmacological evaluation of dotinurad, a selective urate reabsorption inhibitor. J. Pharmacol. Exp. Ther. 371(1), 162-170 (2019).