An inhibitor of the protein-microRNA precursor interaction between Lin28 and let-7
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Lin28 Inhibitor LI71

Item No. 41039

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(3aS,4R,9bR)-6-ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]-benzoic acid
CAS Number
1357248-83-9
Molecular Formula
C21H21NO3
Formula Weight
335.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
CCOC1=C2N[C@@H](C3=CC=C(C=C3)C(O)=O)[C@]4([H])[C@](C=CC4)([H])C2=CC=C1
InChi Code
InChI=1S/C21H21NO3/c1-2-25-18-8-4-7-17-15-5-3-6-16(15)19(22-20(17)18)13-9-11-14(12-10-13)21(23)24/h3-5,7-12,15-16,19,22H,2,6H2,1H3,(H,23,24)/t15-,16+,19+/m1/s1
InChi Key
QWJMABCFVYELBB-GJYPPUQNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $127

    Add

    10 mg

    $570

    Add

    50 mg

    $1,076

    Add

    100 mg

    $1,898

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Lin28 inhibitor LI71 is an inhibitor of the protein-microRNA precursor interaction between the RNA-binding protein Lin28 and let-7.1 It binds to the cold-shock domain of Lin28 to inhibit let-7 binding and inhibits Lin28-mediated let-7 oligouridylation (IC50 = ~27 µM). Lin28 inhibitor LI71 (100 µM) increases the levels of mature let-7b, -7c, -7f, -7g, and -7i as well as the levels of miR-16, which is not regulated by Lin28, in K562 leukemia cells but not the levels of miR-93, miR-99a, and miR-151, which are also not regulated by Lin28. It increases the levels of mature let-7a-i without increasing miR-16 levels in Lin28a/Lin28b double-knockout mouse embryonic stem cells (mESCs) expressing exogenous wild-type Lin28a. Lin28 inhibitor LI71 also inhibits the protein-protein interaction between P. falciparum cold-shock protein (PfCoSP) and PfDNA or Pfα/β-tubulin.2 It is active against P. falciparum strain 3D7 and the chloroquine-resistant strain RKL-9 (IC50s = 1.35 and 6.3 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, L., Rowe, R.G., Jaimes, A., et al. Small-molecule inhibitors disrupt let-7 oligouridylation and release the selective blockade of let-7 processing by LIN28. Cell Rep. 23(10), 3091-3101 (2018).

    2. Behl, A., Shoaib, R., De Leon, F., et al. Targeting an essential Plasmodium cold shock protein to block growth and transmission of malaria parasite. iScience 26(5), 106637 (2023).