An inhibitor of the Hsp90-Cdc37 protein-protein interaction
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Cycle
G1
Cell Biology
Cellular Chaperones

DDO-5936

Item No. 41040

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[[2-(1-pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]-glycine
CAS Number
2355377-13-6
Molecular Formula
C25H29N5O4S
Formula Weight
495.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlChloroform: Slightly Soluble: 0.1-1 mg/mlDMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(CN(S(=O)(C1=C(C)C=C(C)C=C1C)=O)C2=CC=C(NC3=NC(N4CCCC4)=NC=C3)C=C2)O
InChi Code
InChI=1S/C25H29N5O4S/c1-17-14-18(2)24(19(3)15-17)35(33,34)30(16-23(31)32)21-8-6-20(7-9-21)27-22-10-11-26-25(28-22)29-12-4-5-13-29/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H,31,32)(H,26,27,28)
InChi Key
IIPYRKNROAWEPK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $83

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    10 mg

    $141

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    25 mg

    $269

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    50 mg

    $455

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    Cayman Chemical
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    Product Description

    DDO-5936 is an inhibitor of the protein-protein interaction between heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37).1 It inhibits the Hsp90-Cdc37 interaction in HCT116 human colorectal cancer cells when used at concentrations of 5, 10, and 25 µM. DDO-5936 is selective for inhibition of the Hsp90-Cdc37 interaction over inhibition of 20 kinases (IC50s = >100 µM for all) and inhibits the proliferation of HCT116 cells (IC50 = 8.99 µM). It also reduces the levels of the Hsp90 kinase client Cdk4 and induces cell cycle arrest at the G0/G1 phase in a Cdc37-dependent manner in HCT116 cells when used at concentrations of 10 and 25 µM. DDO-5936 (50 and 100 mg/kg per day) reduces tumor growth and tumor weight in an HCT116 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, L., Zhang, L., Li, L., et al. Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer. Sci. Adv. 5(9), eaax2277 (2019).