A DNA ligase I inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

L82-G17

Item No. 41041

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-5-(2-(3-hydroxybenzylidene)hydrazineyl)pyridazin-3(2H)-one
CAS Number
92285-87-5
Molecular Formula
C11H9ClN4O2
Formula Weight
264.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C1NN=CC(NN=CC2=CC(O)=CC=C2)=C1Cl
InChi Code
InChI=1S/C11H9ClN4O2/c12-10-9(6-14-16-11(10)18)15-13-5-7-2-1-3-8(17)4-7/h1-6,17H,(H2,15,16,18)
InChi Key
PYYWVUBALUMAIY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $138

    Add

    10 mg

    $262

    Add

    50 mg

    $1,032

    Add

    100 mg

    $1,513

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    L82-G17 is an uncompetitive inhibitor of DNA ligase I.1 It increases the retention of DNA ligase I, but not DNA ligase III, on nicked DNA-coated beads in a cell-free assay, as well as decreases the proliferation of HeLa cells when used at a concentration of 20 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Howes, T.R.L., Sallmyr, A., Brooks, R., et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst) 60, 29-39 (2017).