A DNA ligase I inhibitor
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L82-G17

Item No. 41041

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-5-(2-(3-hydroxybenzylidene)hydrazineyl)pyridazin-3(2H)-one
CAS Number
92285-87-5
Molecular Formula
C11H9ClN4O2
Formula Weight
264.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C1NN=CC(NN=CC2=CC(O)=CC=C2)=C1Cl
InChi Code
InChI=1S/C11H9ClN4O2/c12-10-9(6-14-16-11(10)18)15-13-5-7-2-1-3-8(17)4-7/h1-6,17H,(H2,15,16,18)
InChi Key
PYYWVUBALUMAIY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $138

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    10 mg

    $262

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    50 mg

    $1,032

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    100 mg

    $1,513

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    Cayman Chemical
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    Product Description

    L82-G17 is an uncompetitive inhibitor of DNA ligase I.1 It increases the retention of DNA ligase I, but not DNA ligase III, on nicked DNA-coated beads in a cell-free assay, as well as decreases the proliferation of HeLa cells when used at a concentration of 20 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Howes, T.R.L., Sallmyr, A., Brooks, R., et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst) 60, 29-39 (2017).