AH 10639 (phosphate)

AH 10639 is an amine-modified pteridine.¹ It selectively inhibits T. gondii dihydrofolate reductase (DHFR; IC₅₀ = 0.033 µM) over DHFR from the pathogenic yeast P. carinii and rat liver (IC₅₀s = 0.2 and 1.1 µM, respectively). AH 10639 reduces T. gondii replication in T. gondii-infected MDBK bovine kidney cells with a mean significant inhibitory (MSI) concentration value of 1 µM and inhibits the uptake of para-aminobenzoic acid, a folate precursor, by P. carinii (IC₅₀ = 16.2 µM). It increases survival in V. cholera-infected mice when administered at a dose of 500 mg/kg.² AH 10639 reduces energy loss and increases thermal stability and power conversion efficiency, as well as improves interfacial contacts, when applied to the fullerene/cathode interface in inverted perovskite solar cells.³

WARNING This product is not for human or veterinary use.

1. Jackson, H.C., Biggadike, K., McKilligin, E., et al. 6,7-disubstituted 2,4-diaminopteridines: Novel inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. Antimicrob. Agents Chemother. 40(6), 1371-1375 (1996).

2. Collier, H.O.J., and Hall, I.F. Studies in the chemotherapy of cholera. VI. Protection by pteridines of mice infected with Vibrio cholerae. Ann. Trop. Med. Parasitol. 45(1), 58-61 (1951).

3. He, Z., Xiong, J., Zhang, Y., et al. Simultaneous realization of bulk and interface regulation based on 2,4-diamino-6,7- diisopropylpteridine phosphate for efficient and stable inverted perovskite solar cells. J. Mater. Chem. A 12, 2309-2322 (2024).