A non-prostaglandin EP2 receptor agonist
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Pro-drug Form(s)
41046Omidenepag Isopropyl
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Omidenepag (free acid)

Item No. 41045

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[6-[[[[4-(1H-pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]-2-pyridinyl]-glycine
CAS Number
1187451-41-7
Synonyms
  • UR-7276
Molecular Formula
C23H22N6O4S
Formula Weight
478.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=[S](N(CC1=CC=C(N2C=CC=N2)C=C1)CC3=CC=CC(NCC(O)=O)=N3)(C4=CN=CC=C4)=O
InChi Code
InChI=1S/C23H22N6O4S/c30-23(31)15-25-22-6-1-4-19(27-22)17-28(34(32,33)21-5-2-11-24-14-21)16-18-7-9-20(10-8-18)29-13-3-12-26-29/h1-14H,15-17H2,(H,25,27)(H,30,31)
InChi Key
YHGSTSNEOJUIRN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Product Description

    Omidenepag is a non-prostaglandin agonist of the prostaglandin E2 (PGE2) receptor subtype EP2 and an active metabolite of the prodrug omidenepag isopropyl ester.1 It selectively binds to human EP2 over EP1, EP3, and EP4 receptors (IC50s = 10, >10,000, >10,000, and 5,480 nM, respectively) and induces cAMP accumulation in HEK293 cells expressing human EP2 receptors (EC50 = 1.1 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iwamura, R., Tanaka, M., Okanari, E., et al. Identification of a selective, non-prostanoid EP2 receptor agonist for the treatment of glaucoma: Omidenepag and its prodrug omidenepag isopropyl. J. Med. Chem. 61(15), 6869-6891 (2018).