Host: E. coli • AA: 630-738 • Tag: N-terminal His • MW: 14.8 kDa
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Ebola Virus Nucleoprotein (subtype Sudan, strain Gulu) (recombinant; aa 630-738)

Item No. 41064

Product Insert (PDF)
Technical Information
Purity
≥95% estimated by SDS-PAGE
Amino Acids
630-738
MW
14.8 kDa
Formulation (Request formulation change)
Lyophilized from sterile 50 mM Tris, 500 mM sodium chloride
UniProt Accession №
Q5XX08
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $384

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    Cayman Chemical
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    Product Description

    Ebola virus (EBOV) is an enveloped and negative-stranded RNA virus, a member of the Ebolavirus genus, and the causative agent of Ebola virus disease (EVD), a condition characterized by a hemorrhagic fever and a high mortality rate, that is endemic to western and equatorial Africa.1 The single-stranded RNA genome of EBOV encodes seven proteins: nucleoprotein (NP), virion protein 40 (VP40), VP35, VP30, VP24, glycoprotein (GP), and an RNA-dependent RNA polymerase (L).1,2 Ebola virus NP is a 739-amino acid protein composed of an N-terminal domain, which is required for protein oligomerization and RNA binding, linked by an unstructured region to a C-terminal domain that functions as a protein-protein interaction hub and forms the viral nucleocapsid that encapsulates the RNA genome throughout the virus life cycle.3,4 This NP nucleocapsid is a protein-RNA complex acts as a scaffold for additional viral proteins, including L, the viral polymerase, to complete viral replication.4 Additionally, the Ebola virus NP is essential to viral genome replication, transcription, and maintenance of viral structure and protects the viral genome from host nucleases.3 Cayman's Ebola Virus Nucleoprotein (subtype Sudan, Strain Gulu) (recombinant; aa 630-738) consists of 108 amino acids and has a calculated molecular weight of 14.8 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is ~18.4 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rojas, M., Monsalve, D.M., Pacheco, Y., et al. Ebola virus disease: An emerging and re-emerging viral threat. J. Autoimmun. 106, 102375 (2020).

    2. Salata, C., Calistri, A., Alvisi, G., et al. Ebola virus entry: From molecular characterization to drug discovery. Viruses 11(3), 274 (2019).

    3. Aceti, D.J., Ahmed, H., Westler, W.M., et al. Fragment screening targeting Ebola virus nucleoprotein C-terminal domain identifies lead candidates. Antiviral Res. 180, 104822 (2020).

    4. Kirchdoerfer, R.N., Saphire, E.O., and Ward, A.B. Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex. Acta Crystallogr. F Struct. Biol. Commun. 75(Pt. 5), 340-347 (2019).