Host: E. coli • AA: 31-326 • Tag: N-terminal His • MW: 34.5 kDa
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Ebola Virus VP40 (subtype Sudan, strain Gulu) (recombinant)

Item No. 41065

Product Insert (PDF)
Technical Information
Synonyms
  • EBOV Matrix Protein VP40
  • EBOV Viral Protein 40
  • EBOV Virion Protein 40
Purity
≥80% estimated by SDS-PAGE
Source
Recombinant Ebola virus N-terminal His-tagged VP40 expressed in E. coli
Amino Acids
31-326
MW
34.5 kDa
Formulation (Request formulation change)
Lyophilized from sterile 50 mM Tris with 500 mM sodium chloride
UniProt Accession №
Q5XX06
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $383

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    Cayman Chemical
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    Product Description

    Ebola virus (EBOV) is an enveloped and negative-stranded RNA virus, a member of the Ebolavirus genus, and the causative agent of Ebola virus disease (EVD), a condition characterized by a hemorrhagic fever and a high mortality rate, that is endemic to western and equatorial Africa.1 The single-stranded RNA genome of EBOV encodes seven proteins: nucleoprotein (NP), virion protein 40 (VP40), VP35, VP30, VP24, glycoprotein (GP), and an RNA-dependent RNA polymerase (L).1,2 EBOV VP40 is a structural protein that is composed of an N-terminal oligomerization domain and a C-terminal domain that interacts with the host intracellular lipid bilayer.3,4 VP40 exhibits oligomeric state-dependent functions, such as adding viral ribonucleocapsids to viral particles when in an octameric form and has roles in viral budding in its hexameric form, when bound to the cytoplasmic side of host lipid membranes.1,4 EBOV VP40 is capable of forming viral-like particles in the absence of other viral proteins when expressed in mammalian cells.4 Cayman's Ebola Virus VP40 (subtype Sudan, strain Gulu) (recombinant) protein consists of 295 amino acids and has a calculated molecular weight of 34.5 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rojas, M., Monsalve, D.M., Pacheco, Y., et al. Ebola virus disease: An emerging and re-emerging viral threat. J. Autoimmun. 106, 102375 (2020).

    2. Salata, C., Calistri, A., Alvisi, G., et al. Ebola virus entry: From molecular characterization to drug discovery. Viruses 11(3), 274 (2019).

    3. Dessen, A., Volchkov, V., Dolnik, O., et al. Crystal structure of the matrix protein VP40 from Ebola virus. EMBO J. 19(16), 4228-4236 (2000).

    4. Jasenosky, L.D., Neumann, G., Lukashevich, I., et al. Ebola virus VP40-induced particle formation and association with the lipid bilayer. J. Virol. 75(11), 5205-5214 (2001).