Host: E. coli • AA: 2-480 (full length) • MW: 54.42 kDa
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NR6A1 (human, recombinant)

Item No. 41073

Product Insert (PDF)
Technical Information
Synonyms
  • GCNF
  • Germ Cell Nuclear Factor
  • Nuclear Receptor 61
  • Nuclear Receptor Subfamily 6 Group A Member 1
  • Retinoid Receptor-related Testis-associated Receptor
  • RTR
Source
Recombinant human NR6A1 expressed in E. coli
Amino Acids
2-480
MW
54.42 kDa
Formulation (Request formulation change)
50 mM Tris-HCl, pH 7.5, with 200 mM sodium chloride, 20% glycerol, and 1 mM DTT
UniProt Accession №
Q15406
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $906

    Add

    500 µg

    $3,090

    Add
    Product Description

    Nuclear receptor subfamily 6 group A member 1 (NR6A1) is a nuclear receptor transcriptional repressor.1,2 NR6A1 primarily is expressed in early embryonic development but it is also expressed in developing spermatid cells in testes and pre-meiotic ovaries.3 Nr6a1 homodimers regulate trunk vertebrae number, trunk elongation, and sacral development, as well as promote neuron-related gene expression in neuromesodermal progenitors, during mouse embryonic development.2 Deletion of Nr6a1 is embryonically lethal in mice. Cayman’s NR6A1 (human, recombinant) protein consists of 479 amino acids and has a calculated molecular weight of 54.42 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, J., Mascarinas, P., and McGlinn , E. The expanding roles of Nr6a1 in development and evolution. Front. Cell Dev. Biol. 12, 1357968 (2024).

    2. Chang, Y.-C., Manent, J., Schroeder, J., et al. Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development. Nat. Commun. 13(1), 7766 (2022).

    3. Chen, F., Cooney, A.J., Wang, Y., et al. Cloning of a novel orphan receptor (GCNF) expressed during germ cell development. Mol. Endocrinol. 8(10), 1434-1444 (1994).