TEAD3 Cofactor-Binding Domain (human, recombinant)

TEA domain transcription factor 3 (TEAD3) is a transcription factor and member of the TEA domain-containing family of transcription factors.¹ It is composed of an N-terminal TEA DNA-binding domain, a hydrophobic proline-rich domain, and a C-terminal cofactor-binding domain (CBD), which binds TAZ or YES-associated transcriptional regulator (YAP), or vestigial-like proteins (VGLLs), and is involved in TAZ-, YAP-, or VGLL-dependent transcription of genes in the Hippo signaling pathway, which regulates embryonic and organ development, proliferation, and cell death.^2,1 TEAD3 associates with VGLL3 to regulate growth and differentiation in primary mouse myoblasts and primary mouse myotubes.³ The tertiary structure and function of TEAD3 require C-terminal palmitoylation at residue 371.⁴ Increased tumor levels of TEAD3 are associated with decreased survival time, increased liver metastases, and reduced time of disease-free survival in patients with pancreatic ductal adenocarcinoma (PDAC).⁵ Cayman's TEAD3 Cofactor-Binding Domain (human, recombinant) protein consists of 219 amino acids, has a calculated molecular weight of 28.5 kDa, and is depalmitoylated at cysteine 371.

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1. Landin-Malt, A., Benhaddou, A., Zider, A., et al. An evolutionary, structural and functional overview of the mammalian TEAD1 and TEAD2 transcription factors. Gene 591(1), 292-303 (2016).

2. Gibault, F., Sturbaut, M., Bailly, F., et al. Targeting transcriptional enhanced associate domains (TEADs). J. Med. Chem. 61(12), 5057-5072 (2018).

3. Figeac, N., Mohamed, A.D., Sun, C., et al. VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle. J. Cell Sci. 132(13), jcs225946 (2019).

4. Noland, C.L., Gierke, S., Schnier, P.D., et al. Palmitoylation of TEAD transcription factors is required for their stability and function in Hippo pathway signaling. Structure 24(1), 179-186 (2016).

5. Drexler, R., Fahy, R., Küchler, M., et al. Association of subcellular localization of TEAD transcription factors with outcome and progression in pancreatic ductal adenocarcinoma. Pancreatology 21(1), 170-179 (2021).