An inhibitor of K2P18.1/TRESK
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A2793

Item No. 41081

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(5-chloro-8-quinolinyl)oxy]-acetic acid, ethyl ester
CAS Number
88349-90-0
Molecular Formula
C13H12ClNO3
Formula Weight
265.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
ClC(C1=C2N=CC=C1)=CC=C2OCC(OCC)=O
InChi Code
InChI=1S/C13H12ClNO3/c1-2-17-12(16)8-18-11-6-5-10(14)9-4-3-7-15-13(9)11/h3-7H,2,8H2,1H3
InChi Key
JEMXUSHXYOXNFL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $31

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    5 mg

    $147

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    10 mg

    $231

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    25 mg

    $424

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    Product Description

    A2793 is an inhibitor of the two-pore domain potassium channel K2P18.1/TRESK (IC50 = 6.8 µM in ionomycin-stimulated Xenopus oocytes expressing the mouse receptor).1 It is selective for K2P18.1/TRESK over K2P2.1/TREK1, K2P10.1/TREK2, K2P4.1/TRAAK, K2P3.2/TASK2, K2P3.3/TASK3, K2P16.1/TALK1, and K2P13.1/THIK1 at 100 µM but does inhibit K2P3.1/TASK1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lengyel, M., Erdélyi, F., Pergel, E., et al. Chemically modified derivatives of the activator compound cloxyquin exert inhibitory effect on TRESK (K2P18.1) background potassium channel. Mol. Pharmacol. 95(6), 652-660 (2019).