A chemiluminescent substrate of luciferase
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Cypridina Luciferin (trifluoroacetate salt)

Item No. 41088

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(3-(2-(sec-butyl)-6-(1H-indol-3-yl)-3-oxo-3,7-dihydroimidazo[1,2-a]pyrazin-8-yl)propyl)guanidine, trifluoroacetate salt
Synonyms
  • Vargulin
  • Vargulin Luciferin
Molecular Formula
C22H27N7O • XCF3COOH
Formula Weight
405.5
Purity
≥95%
Emission
465 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
CCC(C1=NC(N(C=C(N2)C3=CNC4=CC=CC=C43)C1=O)=C2CCCNC(N)=N)C.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C22H27N7O.C2HF3O2/c1-3-13(2)19-21(30)29-12-18(15-11-26-16-8-5-4-7-14(15)16)27-17(20(29)28-19)9-6-10-25-22(23)24;3-2(4,5)1(6)7/h4-5,7-8,11-13,26-27H,3,6,9-10H2,1-2H3,(H4,23,24,25);(H,6,7)
InChi Key
MQQTZTFWGLCOSV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $208

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    1 mg

    $374

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    Cayman Chemical
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    Product Description

    Cypridina luciferin is a chemiluminescent substrate for luciferase.1 Upon hydrolysis by luciferase, it displays a luminescence maximum of 465 nm. Cypridina luciferin has been used in estrogen receptor α (ERα) reporter assays for the discovery of ERα-activating compounds in vitro and in bioluminescence resonance energy transfer (BRET) assays for tumor detection in vivo.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shimomura, O., Johnson, F.H., and Masugi, T. Cypridina bioluminescence: Light-emitting oxyluciferin-luciferase complex. Science 164(3885), 1299-1300 (1969).

    2. Tochigi, Y., Sato, N., Sahara, T., et al. Sensitive and convenient yeast reporter assay for high-throughput analysis by using a secretory luciferase from Cypridina noctiluca. Anal. Chem. 82(13), 5768-5876 (2010).

    3. Wu, C., Mino, K., Akimoto, H., et al. In vivo far-red luminescence imaging of a biomarker based on BRET from Cypridina bioluminescence to an organic dye. Proc. Natl. Acad. Sci. USA 106(37), 15599-15603 (2009).