A disulfide bond-containing ionizable cationic lipid
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

2N12B

Item No. 41094

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
bis(2-(octyldisulfaneyl)ethyl) 3,3'-((2-(methyl(3-(2-(octyldisulfaneyl)ethoxy)-3-oxopropyl)amino)ethyl)azanediyl)dipropionate
CAS Number
3067164-96-6
Molecular Formula
C42H82N2O6S6
Formula Weight
903.5
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(OCCSSCCCCCCCC)CCN(CCC(OCCSSCCCCCCCC)=O)CCN(C)CCC(OCCSSCCCCCCCC)=O
InChi Code
InChI=1S/C42H82N2O6S6/c1-5-8-11-14-17-20-34-51-54-37-31-48-40(45)23-26-43(4)29-30-44(27-24-41(46)49-32-38-55-52-35-21-18-15-12-9-6-2)28-25-42(47)50-33-39-56-53-36-22-19-16-13-10-7-3/h5-39H2,1-4H3
InChi Key
SONCREADMFTALP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $132

    Add

    10 mg

    $251

    Add

    25 mg

    $594

    Add
    Cayman Chemical
    Ionizable Lipids – Your Path from R&D to GMP

    Seamlessly bridge your LNP discovery journey from RUO to bulk GLP-tox and GMP excipient-grade material.

    Explore CGMP Lipid Services
    Product Description

    2N12B is a disulfide bond-containing ionizable cationic lipid (pKa = 6.5) that has been used in the generation of lipid nanoparticles (LNPs) for siRNA delivery in vitro and in vivo.1 LNPs containing 2N12B and encapsulating siRNA targeting VEGFA mRNA reduce VEGFA levels in ARPE-19 retinal pigment cells, as well as reduce migration of human umbilical vein endothelial cells (HUVECs) in a wound healing assay. LNPs containing 2N12B and encapsulating siRNA targeting Vegfa mRNA reduce Vegfa levels in isolated mouse retina, as well as inhibit retinal angiogenesis and decrease fundus vessel leakage, in a mouse model of oxygen-induced retinopathy.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cao, X., Su, L., and Chen, H. A potent bioreducible ionizable lipid nanoparticle enables siRNA delivery for retinal neovascularization inhibition. Eur. J. Pharm. Biopharm. 199, 114296 (2024).