A taccalonolide with anticancer activity
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Taccalonolide B

Item No. 41098

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5α)-1α,11α,12α-tris(acetyloxy)-2α,3α-epoxy-7β,15α,23,25S-tetrahydroxy-6-oxo-γ-lactone, 16β,24β-cycloergost-22-en-26-oic acid
CAS Number
108885-69-4
Molecular Formula
C34H44O13
Formula Weight
660.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly Soluble: 0.1-1 mg/mlDMSO: Sparingly Soluble: 1-10 mg/mlMethanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
[H][C@]12[C@@H]([C@H](OC(C)=O)[C@]3(C)[C@]4([C@@H](C=C5OC([C@](C)([C@@]5([C@]([C@@H]([C@]3([C@]([C@@H](O)C([C@]6(C[C@@]7(O[C@]([C@@H]([C@@]62C)OC(C)=O)7[H])[H])[H])=O)1[H])[H])O)4[H])C)O)=O)C)[H])OC(C)=O
InChi Code
InChI=1S/C34H44O13/c1-11-9-17-33(7,34(8,42)30(41)47-17)22-19(11)32(6)20(25(22)40)18-21(27(43-12(2)35)29(32)45-14(4)37)31(5)15(23(38)24(18)39)10-16-26(46-16)28(31)44-13(3)36/h9,11,15-16,18-22,24-29,39-40,42H,10H2,1-8H3/t11-,15-,16+,18+,19+,20-,21-,22+,24-,25-,26+,27+,28+,29+,31+,32-,33+,34-/m1/s1
InChi Key
FFQOXBQSZPYHSA-MPOUNFKCSA-N
Origin
Plant/Tacca chantrieri
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $87

    Add

    5 mg

    $261

    Add

    10 mg

    $435

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Taccalonolide B is a taccalonolide that has been found in T. chantrieri and has anticancer activity.1 It induces microtubule bundling, formation of abnormal mitotic spindles, and cell cycle arrest at the G2/M phase in HeLa cervical cancer cells when used at a concentration of 0.8 µM. Taccalonolide B decreases the proliferation of HeLa cells (IC50 = 190 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peng, J., Risinger, A.L., Fest, G.A., et al. Identification and biological activities of new taccalonolide microtubule stabilizers. J. Med. Chem. 54(17), 6117-6124 (2011).