An inhibitor of Factor XIa
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BAY-2433334

Item No. 41101

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αS)-N-[4-(aminocarbonyl)-3-fluorophenyl]-4-[5-chloro-2-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl]-α-ethyl-5-methoxy-2-oxo-1(2H)-pyridineacetamide
CAS Number
2064121-65-7
Synonyms
  • Asundexian
Molecular Formula
C26H21ClF4N6O4
Formula Weight
592.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
COC(C(C1=C(N2C=C(N=N2)C(F)(F)F)C=CC(Cl)=C1)=C3)=CN([C@@H](CC)C(NC4=CC(F)=C(C(N)=O)C=C4)=O)C3=O
InChi Code
InChI=1S/C26H21ClF4N6O4/c1-3-19(25(40)33-14-5-6-15(24(32)39)18(28)9-14)36-11-21(41-2)17(10-23(36)38)16-8-13(27)4-7-20(16)37-12-22(34-35-37)26(29,30)31/h4-12,19H,3H2,1-2H3,(H2,32,39)(H,33,40)/t19-/m0/s1
InChi Key
XYWIPYBIIRTJMM-IBGZPJMESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $137

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    5 mg

    $614

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    10 mg

    $1,023

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    25 mg

    $1,876

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    Product Description

    BAY-2433334 is an inhibitor of Factor XIa (IC50 = 0.92 nM).1 It is greater than 1,000-fold selective for Factor Xa over FVIIa, FIXa, FXa, thrombin, urokinase, tissue plasminogen activator, and plasmin. BAY-2433334 increases clotting time in isolated human plasma (EC150 = 0.2 µM). In vivo, BAY-2433334 (10 and 30 mg/kg) reduces thrombus weight in a rabbit model of thrombosis induced by ferric chloride injury of the carotid artery.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. George, I., Bish, L.T., Kamalakkannan, G., et al. Myostatin activation in patients with advanced heart failure and after mechanical unloading. Eur. J. Heart Fail. 12(5), 444-453 (2010).