A Bcl-6 inhibitor
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BI-3812

Item No. 41114

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[5-chloro-4-[[1,2-dihydro-8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxo-6-quinolinyl]amino]-2-pyrimidinyl]-N,N-dimethyl-4-piperidinecarboxamide
CAS Number
2166387-64-8
Molecular Formula
C26H32ClN7O5
Formula Weight
558.0
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1C(OCC(NC)=O)=CC2=C(N1C)C(OC)=CC(NC3=NC(N4CCC(CC4)C(N(C)C)=O)=NC=C3Cl)=C2
InChi Code
InChI=1S/C26H32ClN7O5/c1-28-21(35)14-39-20-11-16-10-17(12-19(38-5)22(16)33(4)25(20)37)30-23-18(27)13-29-26(31-23)34-8-6-15(7-9-34)24(36)32(2)3/h10-13,15H,6-9,14H2,1-5H3,(H,28,35)(H,29,30,31)
InChi Key
XCGYXEVLQIIEJH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $260

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    10 mg

    $455

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    25 mg

    $812

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    Cayman Chemical
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    Product Description

    BI-3812 is an inhibitor of the oncogenic transcription factor Bcl-6 (IC50 = <3 nM).1 It inhibits the growth of NALM1, NALM6, Kasumi-2, and Kasumi-7 leukemia cells when used at concentrations of 3 and 10 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kerres, N., Steurer, S., Schlager, S., et al. Chemically induced degradation of the oncogenic transcription factor BCL6. Cell. Rep. 20(12), 2860-2875 (2017).

    2. Tsuzuki, S., Yasuda, T., Goto, H., et al. BCL6 inhibition ameliorates resistance to ruxolitinib in CRLF2-rearranged acute lymphoblastic leukemia. Haematologica 108(2), 394-408 (2023).