A MAGL inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

JNJ-42226314

Item No. 41115

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[4-[1-[[1-(4-fluorophenyl)-1H-indol-5-yl]carbonyl]-3-azetidinyl]-1-piperazinyl]-2-thiazolyl-methanone
CAS Number
1252765-13-1
Molecular Formula
C26H24FN5O2S
Formula Weight
489.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(N1CCN(C2CN(C2)C(C3=CC(C=CN4C5=CC=C(C=C5)F)=C4C=C3)=O)CC1)C6=NC=CS6
InChi Code
InChI=1S/C26H24FN5O2S/c27-20-2-4-21(5-3-20)32-9-7-18-15-19(1-6-23(18)32)25(33)31-16-22(17-31)29-10-12-30(13-11-29)26(34)24-28-8-14-35-24/h1-9,14-15,22H,10-13,16-17H2
InChi Key
IVOACCSOISMVBL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $32

    Add

    5 mg

    $145

    Add

    10 mg

    $240

    Add

    25 mg

    $479

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    JNJ-42226314 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 10 nM).1 It is selective for MAGL over a panel of 15 serine proteases at 10 µM. JNJ-42226314 (30 mg/kg) increases the latency to paw withdrawal in the hot plate test and the brain levels of 2-arachidonoyl glycerol (2-AG; Item No. 62160) in rats. It increases the latency to fall asleep and the development of non-rapid eye movement (NREM) and REM sleep, as well as increases the cortical levels of norepinephrine, in rats when administered at a dose of 30 mg/kg.2 Radiolabeled forms of JNJ-42226314 have been used for autoradiography and PET tracers for MAGL in the brains of rats and rhesus monkeys.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhu, B., Connolly, P.J., Zhang, Y.M., et al. The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors. Bioorg. Med. Chem. Lett. 30(14), 127243 (2020).

    2. Wyatt, R.M., Fraser, I., Welty, N., et al. Pharmacologic characterization of JNJ-42226314, [1-(4-fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a reversible, selective, and potent monoacylglycerol lipase inhibitor. J. Pharmacol. Exp. Ther. 372(3), 339-353 (2020).

    3. Rong, J., Mori, W., Xia, X., et al. Novel reversible-binding PET ligands for imaging monoacylglycerol lipase based on the piperazinyl azetidine scaffold. J. Med. Chem. 64(19), 14283-14298 (2021).