An inhibitor of UDP-glucose ceramide glucosyltransferase
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

TP-060

Item No. 41127

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydro-2-[4-(1-hydroxy-1-methylethyl)phenyl]-1H-pyrrolo[3,4-c]pyridin-1-one
CAS Number
2601393-20-6
Synonyms
  • T-036
Molecular Formula
C24H20F4N2O3
Formula Weight
460.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C1C2=C(CN1C3=CC=C(C(C)(C)O)C=C3)C(C4=C(OCC(F)(F)F)C=C(F)C=C4)=NC=C2
InChi Code
InChI=1S/C24H20F4N2O3/c1-23(2,32)14-3-6-16(7-4-14)30-12-19-17(22(30)31)9-10-29-21(19)18-8-5-15(25)11-20(18)33-13-24(26,27)28/h3-11,32H,12-13H2,1-2H3
InChi Key
OAZAPIKYVGRNCO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $109

    Add

    5 mg

    $191

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    TP-060 is an inhibitor of UDP-glucose ceramide glucosyltransferase (IC50 = 0.031 µM).1 It is selective for UDP-glucose ceramide glucosyltransferase over human ether-a-go-go (hERG) at 10 µM but also inhibits serotonin receptors (5-HT; IC50 = 0.31 µM). In vivo, TP-060 (30 mg/kg per day) decreases the cerebral cortex and serum levels of glucosylceramide and glucosylsphingosine in a Gba D409V transgenic mouse model of Gaucher disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tanaka, Y., Seto, M., Kakegawa, K., et al. Discovery of brain-penetrant glucosylceramide synthase inhibitors with a novel pharmacophore. J. Med. Chem. 65(5), 4270-4290 (2022).

    2. Fujii, T., Tanaka, Y., Oki, H., et al. A new brain-penetrant glucosylceramide synthase inhibitor as potential Therapeutics for Gaucher disease. J. Neurochem. 159(3), 543-553 (2021).