A derivative of BBT594
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals

BGG463

Item No. 41146

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[[6-(acetylamino)-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-1-naphthalenecarboxamide
CAS Number
890129-26-7
Synonyms
  • K03859
  • NVP-BGG463
Molecular Formula
C30H29F3N6O3
Formula Weight
578.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlMethanol: Sparingly soluble: 1-10 mg/ml
SMILES
CC(NC1=CC(OC2=CC=C3C(C(NC(C=C4C(F)(F)F)=CC=C4CN5CCN(CC5)C)=O)=CC=CC3=C2)=NC=N1)=O
InChi Code
InChI=1S/C30H29F3N6O3/c1-19(40)36-27-16-28(35-18-34-27)42-23-8-9-24-20(14-23)4-3-5-25(24)29(41)37-22-7-6-21(26(15-22)30(31,32)33)17-39-12-10-38(2)11-13-39/h3-9,14-16,18H,10-13,17H2,1-2H3,(H,37,41)(H,34,35,36,40)
InChi Key
MZZJNOOADWVFPD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $39

    Add

    5 mg

    $164

    Add

    10 mg

    $270

    Add

    25 mg

    $482

    Add
    Product Description

    BGG463 is a derivative of BBT594, an inhibitor of the fusion protein Bcr-AblT315I.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Manley, P.W., Brüggen, J., Floersheimer, A., et al. Rational design of T3151 BCR-abl inhibitors for the treatment of drug-resistant chronic myelogenous leukemia (CML): BGG463. Med. Chem. 62(7/8), 579 (2008).