A 17β-HSD13 inhibitor
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BI-3231

Item No. 41147

Technical Information
Formal Name
1-[[5-(2,4-difluoro-3-hydroxyphenyl)-1,3,4-thiadiazol-2-yl]methyl]-3-ethyl-5-methyl-2,4(1H,3H)-pyrimidinedione
CAS Number
2894848-07-6
Molecular Formula
C16H14F2N4O3S
Formula Weight
Purity
≥98%
Formulation
A solid
DMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(N(CC)C(C(C)=C1)=O)N1CC2=NN=C(C3=C(F)C(O)=C(F)C=C3)S2
InChi Code
InChI=1S/C16H14F2N4O3S/c1-3-22-15(24)8(2)6-21(16(22)25)7-11-19-20-14(26-11)9-4-5-10(17)13(23)12(9)18/h4-6,23H,3,7H2,1-2H3
InChi Key
XKDHFIPNTTUSIA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    BI-3231 is an inhibitor of 17β-hydroxysteroid dehydrogenase 13 (17β-HSD13; Ki = 0.7 nM), also known as HSD17B13.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thamm, S., Willwacher, M.K., Aspnes, G.E., et alDiscovery of a novel potent and selective HSD17B13 inhibitor, BI-3231, a well-characterized chemical probe available for open science. J. Med. Chem. 66(4), 2832-2850 (2023).