A BCAT1 and BCAT2 inhibitor
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BAY-069

Item No. 41149

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3R-[4-chloro-3-(2-methylphenoxy)-1-naphthalenyl]-6-(trifluoromethyl)-2,4(1H,3H)-pyrimidinedione
CAS Number
2639638-66-5
Molecular Formula
C22H14ClF3N2O3
Formula Weight
446.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
FC(F)(C1=CC(N(C(N1)=O)C2=CC(OC3=C(C=CC=C3)C)=C(Cl)C4=C2C=CC=C4)=O)F
InChi Code
InChI=1S/C22H14ClF3N2O3/c1-12-6-2-5-9-16(12)31-17-10-15(13-7-3-4-8-14(13)20(17)23)28-19(29)11-18(22(24,25)26)27-21(28)30/h2-11H,1H3,(H,27,30)
InChi Key
UNSHMXUHOHBLIQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $87

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    5 mg

    $348

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    10 mg

    $522

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    25 mg

    $1,087

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    Cayman Chemical
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    Product Description

    BAY-069 is an inhibitor of branched-chain amino acid transaminase 1 (BCAT1) and BCAT2 (IC50s = 31 and 153 nM, respectively).1 It is selective for BCAT1 and BCAT2 over a panel of 77 enzymes, receptors, and transporters at 10 µM. BAY-069 increases the levels of branched-chain amino acids (BCAAs) in U87MG brain and MDA-MB-231 breast cancer cells (IC50s = 358 and 874 nM, respectively) but not in the presence of human serum albumin (HSA) or BSA (IC50s = >50 µM for both).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Günther, J., Hillig, R.C., Zimmermann, K., et al. BAY-069, a novel (trifluoromethyl)pyrimidinedione-based BCAT1/2 inhibitor and chemical probe. J. Med. Chem. 65(21), 14366-14390 (2024).