An inducer of ferroptosis
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Ferroptosis Inducer 24

Item No. 41201

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-phenyl-2-propenoic acid, 2-(1H-indol-3-yl)ethyl ester
CAS Number
28657-88-7
Molecular Formula
C19H17NO2
Formula Weight
291.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(/C=C/C1=CC=CC=C1)OCCC2=CNC3=CC=CC=C32
InChi Code
InChI=1S/C19H17NO2/c21-19(11-10-15-6-2-1-3-7-15)22-13-12-16-14-20-18-9-5-4-8-17(16)18/h1-11,14,20H,12-13H2/b11-10+
InChi Key
UKBRRPUKMUGTQR-ZHACJKMWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $164

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    10 mg

    $290

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    Cayman Chemical
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    Product Description

    Ferroptosis inducer 24 is an inducer of ferroptosis.1 It inhibits glutathione peroxidase 4 (GPX4) by 30-35% when used at a concentration of 50 µM. Ferroptosis inducer 24 (10 µM) increases the levels of heme oxygenase-1 (HO-1) in MDA-MB-231 triple-negative breast cancer cells, as well as increases the levels of bilirubin formed by HO-1 in MDA-MB-231 cell lysates. It reduces the viability of, as well as increases the levels of oxidized lipids, decreases the levels of IL-6 and glutathione (GST), and disrupts the mitochondrial membrane potential in, MDA-MB-231 cancer cells when used at a concentration of 50 µM. Ferroptosis inducer 24 also increases the levels of reactive oxygen species (ROS) in a time-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Consoli, V., Fallica, A.N., Virzì, N.F., et al. Synthesis and in vitro evaluation of CAPE derivatives as ferroptosis inducers in triple negative breast cancer. ACS Med. Chem. Lett. 15(5), 706-713 (2024).