An ionizable cationic lipid
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Lipid HTO12

Item No. 41202

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-[(2-hydroxyethyl)(2-hydroxytetradecyl)amino]-octanoic acid, 1-octylnonyl ester
CAS Number
3047222-45-4
Molecular Formula
C41H83NO4
Formula Weight
654.1
Purity
≥98%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
OCCN(CC(O)CCCCCCCCCCCC)CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O
InChi Code
InChI=1S/C41H83NO4/c1-4-7-10-13-16-17-18-19-21-26-31-39(44)38-42(36-37-43)35-30-25-20-24-29-34-41(45)46-40(32-27-22-14-11-8-5-2)33-28-23-15-12-9-6-3/h39-40,43-44H,4-38H2,1-3H3
InChi Key
AXNSKPOIXOXYSH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $196

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    25 mg

    $464

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    50 mg

    $818

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    Cayman Chemical
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    Product Description

    Lipid HTO12 is an ionizable cationic lipid (pKa = 6.432) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing lipid HTO12 and encapsulating adenine base editor mRNA targeting Pcsk9 reduce hepatic Pcsk9 levels in mice at a reduced ionizable lipid/total lipids-to-mRNA ratio than LNPs containing SM-102 (Item No. 33474).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, Q., Wang, X., Zhang, Y., et al. Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editing. Natl. Sci. Rev. 11(6), nwae135 (2024).