Host: Insect cells • AA: 790-895 • Tag: C-terminal His • MW: 14.58 kDa
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Product Categories

Product Type

Proteins

Research Area

Immunology & Inflammation
Innate Immunity

Application

Western Blot

CD163L1 SRCR8 Domain (human, recombinant)

Item No. 41208

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CD163B
  • CD163L1
  • CD163 Antigen B
  • CD163 Antigen-like 1
  • CD163 Molecule-like 1
  • hCD163L SRCR8
  • M160
  • Scavenger Receptor Cysteine-rich Type 1 Protein M160
Purity
≥85% estimated by SDS-PAGE
Source
Recombinant human C-terminal His-tagged CD163L1 SRCR8 domain expressed in insect cells
Amino Acids
790-895
MW
14.58 kDa
Formulation (Request formulation change)
20 mM Tris, pH 8.0, 100 mM sodium chloride
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    20 µg

    $418

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    Product Description

    CD163 molecule-like 1 (CD163L1), also known as CD163 antigen B (CD163B), is an extracellular membrane receptor and a member of the scavenger receptor cysteine-rich (SRCR) family.1,2 It is composed of an N-terminal ectodomain, which contains 12 disulfide-rich SRCR class B domains that mediate protein-protein interactions, a transmembrane segment, and a short cytoplasmic tail.1 Alternative splicing of CD163L1 mRNA produces two variants that differ in length of the cytoplasmic tail.1,3 CD163L1 is found in monocytes and M2 macrophages and can be induced by colony-stimulating factor 1 (CSF1) and IL-10 in macrophages.3 Replacement of porcine CD163L1 SRCR5 domain with human CD163L1 SRCR8 domain increases resistance to porcine reproductive and respiratory syndrome virus 1 (PRRSV1) infection in pigs.4 Cayman's CD163L1 SRCR8 Domain (human, recombinant) protein consists of 105 amino acids and has a calculated molecular weight of 14.58 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grønlund, J., Vitved, L., Lausen, M., et al. Cloning of a novel scavenger receptor cysteine-rich type I transmembrane molecule (M160) expressed by human macrophages. J. Immunol. 165(11), 6406-6415 (2000).

    2. Etzerodt, A., and Moestrup, S.K. CD163 and inflammation: Biological, diagnostic, and therapeutic aspects. Antioxid. Redox Signal. 18(17), 2352-2363 (2013).

    3. González-Domínguez, É., Samaniego, R., Flores-Sevilla, J.L., et al. CD163L1 and CLEC5A discriminate subsets of human resident and inflammatory macrophages in vivo. J. Leukoc. Biol. 98(4), 453-466 (2015).

    4. Wells, K.D., Bardot, R., Whitworth, K.M., et al. Replacement of porcine CD163 scavenger receptor cysteine-rich domain 5 with a CD163-like homolog confers resistance of pigs to genotype 1 but not genotype 2 porcine reproductive and respiratory syndrome virus. J. Virol. 91(2), e01521-e015316 (2017).