A radiosensitizer and a prodrug form of idoxuridine
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Active Metabolite(s)
20222Idoxuridine
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Ropidoxuridine

Item No. 41220

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-2(1H)-pyrimidinone
CAS Number
93265-81-7
Synonyms
  • IPdR
  • 5-Iodo-2-pyrimidinone-2'-deoxyribose
Molecular Formula
C9H11IN2O4
Formula Weight
338.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O[C@@H]1[C@@H](CO)O[C@@H](N2C=C(I)C=NC2=O)C1
InChi Code
InChI=1S/C9H11IN2O4/c10-5-2-11-9(15)12(3-5)8-1-6(14)7(4-13)16-8/h2-3,6-8,13-14H,1,4H2/t6-,7+,8+/m0/s1
InChi Key
XIJXHOVKJAXCGJ-XLPZGREQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $219

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    10 mg

    $416

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    25 mg

    $986

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    50 mg

    $1,643

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    Product Description

    Ropidoxuridine is a radiosensitizer and a prodrug form of the antiviral compound idoxuridine (Item No. 20222).1 It also inhibits viral plaque formation in HeLa cells infected by herpes simplex virus 1 (HSV-1) or HSV-2 when used at a concentration of 100 µM.2 Ropidoxuridine (1,000 mg/kg per day for six days) enhances radiation-induced decreases in tumor growth without reducing body weight in an HT-29 colon cancer mouse xenograft model.1 It increases animal survival in a mouse model of lethal HSV-2 infection when administered at a dose of 100 mg/kg every five days.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kinsella, T.J., Kunugi, K.A., Vielhuber, K.A., et al. Preclinical evaluation of 5-iodo-2-pyrimidinone-2'-deoxyribose as a prodrug for 5-iodo-2'-deoxyuridine-mediated radiosensitization in mouse and human tissues. Clin. Cancer Res. 4(1), 99-109 (1998).

    2. Lewandowski, G.A., Grill, S.P., Fisher, M.H., et al. Anti-herpes simplex virus activity of 5-substituted 2-pyrimidinone nucleosides. Antimicrob. Agents Chemother. 33(3), 340-344 (1989).