A taccalonolide with anticancer activity
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Taccalonolide AJ

Item No. 41223

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,2α,3α,5α,7β,11α,12α,15α,16β,22R,23R,25S)-1,11,12-tris(acetyloxy)-2,3:22,23-diepoxy-7,15,23,25-tetrahydroxy-6-oxo-16,24-cycloergostan-26-oic acid, γ-lactone
CAS Number
2230777-09-8
Molecular Formula
C34H44O14
Formula Weight
676.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Sparingly soluble: 1-10 mg/mlMethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
C[C@]12[C@@]3(OC([C@]2(O)C)=O)[C@]([C@H]([C@@]4([H])[C@@]1([H])[C@@H]([C@]5([H])[C@@]4([C@@H](OC(C)=O)[C@H]([C@@]6([H])[C@@]5([H])[C@H](C([C@]7([H])[C@@]6([C@H]([C@]8([H])[C@](O8)([H])C7)OC(C)=O)C)=O)O)OC(C)=O)C)O)C)([H])O3
InChi Code
InChI=1S/C34H44O14/c1-10-17-20(32(7)33(8,42)29(41)48-34(32)26(10)47-34)23(40)18-16-19(25(43-11(2)35)28(31(17,18)6)45-13(4)37)30(5)14(21(38)22(16)39)9-15-24(46-15)27(30)44-12(3)36/h10,14-20,22-28,39-40,42H,9H2,1-8H3/t10-,14+,15-,16-,17-,18+,19+,20-,22+,23+,24-,25-,26+,27-,28-,30-,31+,32-,33+,34-/m0/s1
InChi Key
BWKYBGRKQMTOQL-BTEOCCBTSA-N
Origin
Plant/Tacca chantieri André
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Taccalonolide AJ is a taccalonolide that has been found in plants of the genus Tacca and has anticancer activity.1 It enhances microtubule polymerization in a cell-free assay when used at concentrations ranging from 5 to 30 µM. Taccalonolide AJ inhibits the proliferation of HeLa cells (IC50 = 4 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Risinger, A.L., Li, J., Bennett, M.J., et al. Taccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity. Cancer Res. 73(22), 6780-6792 (2013).