An inhibitor of bacterial β-glucuronidase
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β-Glucuronidase Inhibitor

Item No. 41228

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1,2-dihydro-6,8-dimethyl-2-oxo-3-quinolinyl)methyl]-N′-(4-ethoxyphenyl)-N-(2-hydroxyethyl-thiourea
CAS Number
484006-66-8
Molecular Formula
C23H27N3O3S
Formula Weight
425.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C1NC2=C(C=C1CN(CCO)C(NC3=CC=C(C=C3)OCC)=S)C=C(C)C=C2C
InChi Code
InChI=1S/C23H27N3O3S/c1-4-29-20-7-5-19(6-8-20)24-23(30)26(9-10-27)14-18-13-17-12-15(2)11-16(3)21(17)25-22(18)28/h5-8,11-13,27H,4,9-10,14H2,1-3H3,(H,24,30)(H,25,28)
InChi Key
PSKUPWXOVUAUJD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    β-Glucuronidase inhibitor is an inhibitor of bacterial β-glucuronidase (IC50 = 283 nM for the E. coli enzyme).1 It inhibits wild-type but not Δ360-376 E. coli β-glucuronidase, a mutant lacking the bacteria-specific loop, when used at a concentration of 100 µM. In vivo, β-glucuronidase inhibitor (50 mg/kg) reduces colonic epithelial damage and the number of bloody diarrheal events induced by irinotecan (CPT-11) in a mouse model of chemotherapy-induced intestinal toxicity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wallace, B.D., Wang, H., Lane, K.T., et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science 330(6005), 831-835 (2010).