A GCGR negative allosteric modulator
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NNC-0640

Item No. 41234

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(4-cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2H-tetrazol-5-yl-benzamide
CAS Number
307986-98-7
Molecular Formula
C29H31N7O4S
Formula Weight
573.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(NC1=CC=CC(S(=O)(C)=O)=C1)N(C2=CC=C(C3CCCCC3)C=C2)CC4=CC=C(C(NC5=NN=NN5)=O)C=C4
InChi Code
InChI=1S/C29H31N7O4S/c1-41(39,40)26-9-5-8-24(18-26)30-29(38)36(25-16-14-22(15-17-25)21-6-3-2-4-7-21)19-20-10-12-23(13-11-20)27(37)31-28-32-34-35-33-28/h5,8-18,21H,2-4,6-7,19H2,1H3,(H,30,38)(H2,31,32,33,34,35,37)
InChi Key
PPTKULJUDJWTSA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $104

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    10 mg

    $193

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    25 mg

    $379

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    Product Description

    NNC-0640 is a negative allosteric modulator of the glucagon receptor (GCGR; Ki = 39.8 nM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jazayeri, A., Doré, A.S., Lamb, D., et al. Extra-helical binding site of a glucagon receptor antagonist. Nature 533(7602), 274-277 (2016).