A cationic quaternary ammonium lipid derivative of SM-102
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Q1-SM-102 (iodide)

Item No. 41239

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-hydroxyethyl)-N-methyl-8-[(1-octylnonyl)oxy]-8-oxo-N-[6-oxo-6-(undecyloxy)hexyl]-1-octanaminium, monoiodide
CAS Number
3079716-72-3
Synonyms
  • Q1-CAY10779
  • Q1-Lipid H
  • Q1-LNP-102
Molecular Formula
C45H90NO5 • I
Formula Weight
852.1
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: Sparingly Soluble: 1-10 mg/ml
SMILES
OCC[N+](CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)(C)CCCCCC(OCCCCCCCCCCC)=O.[I-]
InChi Code
InChI=1S/C45H90NO5.HI/c1-5-8-11-14-17-18-19-25-33-42-50-44(48)36-30-26-32-39-46(4,40-41-47)38-31-24-20-23-29-37-45(49)51-43(34-27-21-15-12-9-6-2)35-28-22-16-13-10-7-3;/h43,47H,5-42H2,1-4H3;1H/q+1;/p-1
InChi Key
OFVAGWVUQMTSAD-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Q1-SM-102 is a cationic quaternary ammonium lipid derivative of the ionizable cationic lipid SM-102 (Item No. 33474) that has been used in the generation of lipid nanoparticles (LNPs) for use in vivo.1 LNPs containing Q1-SM-102 and SM-102 as a cationic lipid pair (CLP) and encapsulating mRNA encoding a luciferase reporter induce luciferase expression in the lungs and spleen in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zeng, G., He, Z., Yang, H., et al. Cationic lipid pairs enhance liver-to-lung tropism of lipid nanoparticles for in vivo mRNA delivery. ACS Appl. Mater. Interfaces 16(20), 25698-25709 (2024).